Cursed from the earth
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καὶ νῦν ἐπικατάρατος σὺ ἐπὶ τῆς γῆς, ἣ ἔχανεν τὸ στόμα αὐτῆς δέξασθαι τὸ αἷμα τοῦ ἀδελφοῦ σου ἐκ τῆς χειρός σου.
ἐπικατάρατος, "cursed," is a real New Testament word — Paul quotes Deut 27:26 and 21:23 with this same adjective at Gal 3:10,13 ("cursed is everyone who…", "Christ… having become a curse [κατάρα] for us"). The earth itself, personified, ἔχανεν τὸ στόμα, "opened its mouth" — the same land that in ch.3 was cursed *because of* Adam's sin (3:17) is now compelled, against its own nature, to drink the blood it did not ask for.
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The Septuagint 4.11 — The Great Library Project interlinear edition · greatlibraryproject.com/book/septuagint/4.11/