"Am I my brother's keeper?"
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καὶ εἶπεν ὁ θεὸς πρὸς Κάιν Ποῦ ἐστιν Ἄβελ ὁ ἀδελφός σου; ὁ δὲ εἶπεν Οὐ γινώσκω· μὴ φύλαξ τοῦ ἀδελφοῦ μου εἰμὶ ἐγώ;
God's question to Cain ("Where is Abel your brother?") deliberately echoes his earlier question to Adam in Eden (3:9, "Where are you?") — the same summons to a hiding, guilty party. Cain's retort turns the LXX's own noun φύλαξ, "a guard, keeper, sentinel," into the most quoted rhetorical question in the chapter: μὴ φύλαξ τοῦ ἀδελφοῦ μου εἰμὶ ἐγώ; The Hebrew has a similar noun (שֹׁמֵר, "keeper, watchman"); the Greek's φύλαξ carries a guard-post's connotation — Cain denying not just care but an assigned duty of watch.
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The Septuagint 4.9 — The Great Library Project interlinear edition · greatlibraryproject.com/book/septuagint/4.9/