Enmity between you and the woman
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καὶ ἔχθραν θήσω ἀνὰ μέσον σοῦ καὶ ἀνὰ μέσον τῆς γυναικός, καὶ ἀνὰ μέσον τοῦ σπέρματός σου καὶ ἀνὰ μέσον τοῦ σπέρματος αὐτῆς· αὐτός σου τηρήσει κεφαλήν, καὶ σὺ τηρήσεις αὐτοῦ πτέρναν.
The most consequential single verse in the chapter for later readers: God sets ἔχθρα, "enmity," permanently between the serpent and the woman, and between their two seeds (σπέρμα — the serpent's own offspring, and hers). "He shall watch/guard your head, and you shall watch his heel" (a mutual, ongoing hostility, not a single blow) has been read since antiquity — well outside the plain sense available to the original Hebrew or LXX audience — as the protevangelium, the first announcement of the gospel: early Christian interpreters (echoed later in Rom 16:20, "the God of peace will soon crush Satan under your feet") saw here a distant prophecy of a descendant of the woman finally overcoming the serpent, its head-wound fatal where the answering heel-wound is not. This is attested Christian reception, not a claim about what the Hebrew or Greek text asserts on its own.
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The Septuagint 3.15 — The Great Library Project interlinear edition · greatlibraryproject.com/book/septuagint/3.15/